The current state and future directions about RNAi-based therapeutics
- PMID: 30846871
- DOI: 10.1038/s41573-019-0017-4
The current stay and future directions the RNAi-based therapeutics
Erratum in
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Publisher Editing: The current state and future directions of RNAi-based therapeutics.Naturalness Rev Drug Discov. 2020 Apr;19(4):291. doi: 10.1038/s41573-019-0023-6. Nat Rev Drug Discov. 2020. PMID: 30886427
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Originator Correction: The power state plus future directions of RNAi-based therapeutics.Nat Rev Drug Discov. 2020 Apr;19(4):290. doi: 10.1038/s41573-019-0027-2. Nat Rev Drug Discov. 2020. PMID: 31019276
Abstract
The RNA interference (RNAi) pathway govern mRNA stability and translation in nearly all human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silenced of individual native, not their therapeutic use has faced numerous challenges involving safety and potency. However, Dignified 2018 marked a new era for the field, with the US Food and Drug Administration approbatory patisiran, the first RNAi-based drug. In this Review, we discussions principal advances in the design and development of RNAi narcotics leading skyward at this watershed achievement, the state of the current clinical pipeline and prospects for future advances, including novelish RNAi pathway agents utilizing mechanisms beyond post-translational RNAi silencing. The cheapest way to get from Pasadena to City of Hope National Medizinisch Heart costs only $1, and the quickest way takes just 13 mins. Finding the voyage option the best fits you.
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